Reproductive toxicology. 2,2-bis(bromomethyl)-1,3-propanediol.
نویسندگان
چکیده
Although it is acknowledged that genetic variation contributes to individual differences in thermotolerance, the specific genes and pathways involved and how they are modulated by the environment remain poorly understood. We link natural variation in the thermotolerance of neural function and behavior in Drosophila melanogaster to the foraging gene (for, which encodes a cGMP-dependent protein kinase (PKG)) as well as to its downstream target, protein phosphatase 2A (PP2A). Genetic and pharmacological manipulations revealed that reduced PKG (or PP2A) activity caused increased thermotolerance of synaptic transmission at the larval neuromuscular junction. Like synaptic transmission, feeding movements were preserved at higher temperatures in larvae with lower PKG levels. In a comparative assay, pharmacological manipulations altering thermotolerance in a central circuit of Locusta migratoria demonstrated conservation of this neuroprotective pathway. In this circuit, either the inhibition of PKG or PP2A induced robust thermotolerance of neural function. We suggest that PKG and therefore the polymorphism associated with the allelic variation in for may provide populations with natural variation in heat stress tolerance. for’s function in behavior is conserved across most organisms, including ants, bees, nematodes, and mammals. PKG’s role in thermotolerance may also apply to these and other species. Natural variation in thermotolerance arising from genes involved in the PKG pathway could impact the evolution of thermotolerance in natural populations.
منابع مشابه
DMD #32110 1 In vitro glucuronidation of 2,2-bis(bromomethyl)-1,3-propanediol by microsomes and hepatocytes from rats and humans
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On the Structure of Some Pentaerythritol-Related Molecular Crystals with Pseudotetrahedral Molecular Structure. Ordered Structure of 2,2-Bis(bromomethyl)-l,3-propanediol and Orientationally Disordered Structure of 2-Chloromethy 1-2-methyl-1,3-dichloropropane; C1 NQR*
für Naturforschung in cooperation with the Max Planck Society for the Advancement of Science under a Creative Commons Attribution 4.0 International License. Dieses Werk wurde im Jahr 2013 vom Verlag Zeitschrift für Naturforschung in Zusammenarbeit mit der Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. digitalisiert und unter folgender Lizenz veröffentlicht: Creative Commons Namen...
متن کاملIn vitro glucuronidation of 2,2-bis(bromomethyl)-1,3-propanediol by microsomes and hepatocytes from rats and humans.
2,2-Bis(bromomethyl)-1,3-propanediol (BMP) is a brominated flame retardant used in unsaturated polyester resins. In a 2-year bioassay BMP was shown to be a multisite carcinogen in rats and mice. Because glucuronidation is the key metabolic transformation of BMP by rats, in this study the in vitro hepatic glucuronidation of BMP was compared across several species. In addition, the glucuronidatio...
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متن کاملسنتز و مشخصه یابی پلی(2،2- بیس(آزیدو‌متیل)-3،1-پروپیلن‌آدیپات) به عنوان بایندر پرانرژی
polyester polyol can be used in high energy propellant as a binder.In this research, polyazido polyester was synthesized from direct polycondensation reaction between adipic acid and 2,2-bis(bromomethyl)-1,3-propanediol. Then, azidation of poly bromoester afford polyazidoester as an energetic polyester. polyazidoester have identified and characterized by FTIR,HNMR,GPC,DSC and elemental analysis...
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عنوان ژورنال:
- Environmental Health Perspectives
دوره 105 شماره
صفحات -
تاریخ انتشار 1997